Congratulations Dr Magda Ali!

Congratulations Dr Magda Ali! Our latest successful PhD viva was from the amazing Magda, finishing off a great PhD.

Well done Magda!

Interview on "Becoming a Scientist: The Graphic Novel"

I was recently interviewed by the Hindustan Times on our book, "Becoming a Scientist". Here is the transcript in full:

Tell us a bit about you and the Liston-Dooley Lab. Apart from researching how to keep the body’s immune response in check, you have also been working on improving equality of opportunity within science careers, communicating science to children through online games and books. What makes you want to update how scientific communication works today? Do you feel that there is much that people do not know about science as a field? 

Science is building knowledge faster than any person can learn, so there is always more science to communicate. This project, however, was really about filling that gap in understanding what a scientist is. The pop media tends to portray scientists as solo geniuses, capable of tinkering around and coming up with insights other people just don't have the innate ability for. That really isn't how science works - anyone could become a scientist. Science is really just about training up your curiosity, learning a few tools, being resilient to failure, and following the data over your pre-conceptions. That's it!

Tell us a bit about your own journey. You had never met a scientist and would probably have ended up as a truck driver too had you not been lucky enough to land a scholarship. Looking back, do you wish things were different for you? 

Everyone makes mistakes in their own journey, I'd rather just look at making a better path forward. I talk to a lot of early career scientists who worry about making a detour in their career through the "wrong" choice. Over and over, what I see is that it is the detours that give you a unique perspective, and in science the ability to look at an old question from a new angle is incredibly valuable. So I say be willing to take a risk and embrace the odd detour in your journey!

If making it to college was not enough, you have touched upon class snobbery and the feeling of alienation that not many people speak about. Tell us how challenging it is and how did you overcome these difficult moments? Is it something you have seen several other colleagues from not very affluent backgrounds also facing? 

I'm proud of being working class. For sure it led some people to dismiss me or look down on me, that is the point of class borders. But it is who I am, and I think it is actually a great preparation for being a scientist. Working at the very edge of human knowledge means floundering and flailing and believing the data when it tells you that you are wrong; over-confidence is the biggest risk in a scientist, while perseverance and humility are virtues. 

What are the biggest challenges that plague the scientific community today? Jargon, for instance, is one that you have avoided in your books. 

So many challenges! Funding is an obvious one. Investment in science generates more economic gains than the expenditure, but it takes time to reap the benefits. So even though it is a win-win situation, short-term pressures often stunt the growth of research budgets - you wouldn't believe the advances that are being held back just by a lack of investment. We have a potential treatment for traumatic brain injury that is waiting for funding to allow us to move to clinical trials - it can be very frustrating!

Perhaps contributing to this problem is the increase in deliberate misinformation. No one can have a solid understanding of the breadth of science, even active scientists, so I don't begrudge anyone having misconceptions or accidently passing them on. Unfortunately at the moment we have a serious problem of people deliberately spreading misinformation for political gain. Whether it is climate change, vaccination, stem cells, or any other topic, we are seeing a systematic effort to degrade the public's ability to determine fact from fiction. In a very real way, it undermines the foundations of our technology-driven civilisation. 

From children’s books to an online game and now a graphic novel, what do you keep in mind while evolving in terms of medium, language and message to reach out to a young audience. 

The only way you reach someone is to go out and meet them where they are. Anything else is just preaching to the choir or screaming into the void. If you want to connect to someone, learn their language and enter their place. 

Why did you decide to tell the stories of these 12 scientists? Was there a particular incident that triggered the thought? How do you think it can help more children consider science as a potential career, irrespective of where they are in life? 

These stories were not hunted down, they were the 12 lab members of my lab at the time I wrote the book. I genuinely believe everyone's story is interesting, so I try to learn about my team. My son is nearing the stage where he is thinking about careers, and of course he has a good idea of what a scientist looks like and how they think, but so many kids won't have that opportunity. So I thought I could write the stories of my team members and share it with other kids his age.

Once you had the concept in mind how long did it take to collate everyone’s stories, put it down in words and as illustrations and get the book ready? How did the other scientists respond to the idea of seeing their stories become an inspiration for others? Were any of them apprehensive or were they all excited to share their personal journeys? 

When writing about people you know well, it is probably faster to tell their story then it is to tell your own. Initially most of us were apprehensive - it is an insight into us as people, and normally we only write about our science. Putting a window into our hearts out for the whole world is daunting. However the feedback we have received has made everything worth it!

How has the feedback been for the novel? Any heartwarming responses from those who have read it? 

We've had lot of great feedback from scientists, but what means the most to me is hearing from people who resonated with a particular story. For example I've heard from people who came through the foster care system, some of the most disadvantages kids in society, who read James's story and felt uplifted by his success, and are now sharing it with the foster kids they mentor. Sometimes all it takes is one event during your childhood, just one time that you need the epiphany that people like you can succeed, to make a life take a different track.

Positive research culture at the Immunology STEM Village

Today I'm honoured to give a talk on building a positive research culture for the Immunology STEM Village meeting in Manchester. If you can't make it, but are interested in the topic, here is my talk:

Moments before thesis submission...

Lab retreat 2024

Congratulations Dr Ntombizodwa Makuyana!

Congratulations Dr Ntombizodwa Makuyana! Our 24th PhD completion from the lab, and our 1st Cambridge PhD defence! Way to go Tombi! 

Being a scientist

From an interview with Superbugs 

I didn’t really know what a scientist was growing up in Australia. My Dad was a truck driver, and everyone around me either drove trucks or worked in factories. If it wasn’t for watching nature documentaries on the TV, I probably would have dropped out of high school and become a truck driver too. Listening to David Attenborough explain how life was interconnected changed my pathway in life. I had a taste of wondering “why” and hearing it explained, and I wanted to know how the how world worked.

I got good grades in school and went to university. Although, to be honest, you didn’t need especially good grades to get into a science degree – it is rather inclusive entry, unlike medicine or engineering which are tougher to get into. I’m also not especially convinced that the grades you get during your degree in science reflect much about your capacity to be a scientist. The undergraduate degree has to give you the baseline of facts and tools, but once you graduate and become a scientist you are operating at the very boundary of human knowledge. It doesn’t matter if you are quick or slow, have a photographic memory or need to look up basic formulas each time. Science is different from any other walk in life. You can fail and fail and fail, but by succeeding just once you add something new to the sum total of humanity’s knowledge. When I think about what it takes to succeed as a scientist I think it really comes down to three things: creativity, resilience and integrity.

Why creativity, resilience and integrity? Creativity because we don’t know what the right experiments are. Once you are at the boundaries of knowledge, all you can do is take an educated guess, design the best experiment you can, and see if it sheds new light. Most of the time it doesn’t! So a creative scientist is someone who is good at coming up with multiple different ways to attack a problem. Of course, this means a lot of failure, which is where resilience comes in. Failing multiple times is a serious downer. Classical high achievers often struggle when they transition from acing every exam to failing in the lab. If you’ve got grit, if you know how to pick yourself up and try again, then you’ll eventually solve the problem. That is what science is, being wrong over and over again, until in the end you are right. Finally, integrity is key. You’ve just got to be honest in science. To make progress we need to build a tower out of data. People who are willing to fudge their results, fool themselves into thinking they are right when they are not, they start building their tower on poor foundations. The scientists who are willing to admit they are wrong, change their mind with new data, and take the slow route are the ones who end up building the highest.

I guess this doesn’t make science sound super attractive as a career! It is genuinely hard, and few people actually enjoy being wrong over and over again! But the thing is, when you are right, it is amazing. When we find something out it is actually something entire new that we have created – we have moved the sphere of human knowledge further out. There are also a lot of perks to a career in science – I get to travel a lot, don’t need to wear a suit, and the work is easier and for more money than driving a truck or working in a factory!

For myself, after a research career in Australia and America, I started to become more interested in creating a space for scientists to excel in, rather than doing science myself. I moved to Belgium and set up a lab in a hospital there. I tried to bring in a team of amazing people with different skills and backgrounds – biologists, mathematicians, clinicians, engineers, chemists and more, precisely because we never really know the best way to tackle the new problem. My job is to pick the questions we work on, and help the team to find ways to put together their skills to answer those questions. By having a team of diverse people who think in different ways we became much more successful at finding a winning formula. We have uncovered the causes of human diseases, solved riddles for why some patients are sick, started clinical trials that brought new treatments to neglected patients, even developed new drugs. Each success we have opens up a new and more interesting problem, and we are genuinely improving the world.

After a decade in Belgium I moved over my lab to Cambridge. We are still working on interesting problems in pathology, and I still have an amazing team of diverse scientists. Perhaps the best part, though, is that so many people have left my lab and have started up their own teams, in universities, hospitals and biotech companies, all across the world. That decision I made to go into science after high school has led to hundreds of scientists being trained, and humanity will build on the knowledge they create long after I am gone.

Tissue Tregs seminar

Recording of a seminar I gave for the Cytek seminar series, on tissue-resident regulatory T cells.

That's TV Cambridge interview

Meet the nextGEN: James Dooley

An interview with LifeScience.org

Who or what called you to lead?

My journey into leadership started with a deep-rooted desire to care for others, a calling that was shaped by my childhood experiences. Growing up in foster care, I spent a lot of time with my grandmother, who was a kind and caring person. She didn't just take care of me—she took care of everyone around her. Watching her selflessness made me realise early on that I wanted to follow in her footsteps and help people.

At 15, I ran away from home and started working in healthcare. My first jobs were in hospitals and nursing homes, and by my early 20s, I decided to go back to school to become either a paramedic or physician. However, my path took a major turn after I was in a serious car accident, which left me in rehab for two years. The physical toll it took on me made me question whether I could handle the intensity of working in the ER, something my mentor—who had become a close friend—strongly advised me to reconsider.

After another accident in the ER, I realized that my body simply couldn’t endure the demands of the job. So, I shifted my focus to research, with the help of that same mentor who pointed me towards a biotech research program. I was working in immunology at the time, but it wasn’t long before neurology caught my attention. Years later, I crossed into that field after meeting my co-founder, Adrian Liston, when he set up his lab in Belgium.

Adrian’s brother tragically passed away from a traumatic brain injury (TBI), which deeply impacted both of us. That loss shifted our focus toward the huge unmet need for TBI treatments. We started applying the immunological research I had been working on toward neurological solutions, and what we discovered was promising. In transgenic animals, we were able to get effective immune responses in the brain. From there, we realised that with gene therapy, we might be able to translate these findings to humans and potentially save the lives of TBI patients in those critical early stages.

When Adrian moved the lab to the UK, we founded our company and have been dedicated ever since to making this a reality. As a leader, I’m driven by the desire to fill the gaps in healthcare, especially for conditions like TBI, where treatments are sorely lacking. My goal is to translate cutting-edge research into therapies that make a real difference for patients and their families.